TETHERING OF AN E3 LIGASE BY PCM1 REGULATES THE ABUNDANCE OF CENTROSOMAL KIAA0586/TALPID3 AND PROMOTES CILIOGENESIS

Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis

To elucidate the role of centriolar satellites in ciliogenesis, we deleted the gene encoding the PCM1 protein, an integral component of satellites.PCM1 null human cells show marked defects in ciliogenesis, precipitated by the loss of specific proteins from satellites and their relocation to centrioles.We find that an amino-terminal domain of PCM1 c

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Characterization of Lactobacillus rhamnosus MP01 and Lactobacillus plantarum MP02 and Assessment of Their Potential for the Prevention of Gastrointestinal Infections in an Experimental Canine Model

The aim of the present study was to evaluate the probiotic potential of Lactobacillus rhamnosus MP01 and Lactobacillus plantarum MP02, Goalkeeper Jersey two strains isolated from canine milk.These two isolates were characterized in vitro for their survival to conditions similar to those found in the canine gastrointestinal tract, production of anti

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